Blackpool made it eleven games unbeaten but had to battle against a Brentford side who had won the corresponding fixture earlier in the season 5-0.
Steve McMahon's side had far the better of the first half but needed a superb save from Phil Barnes in the second to secure the three points after a barrage of pressure from the visitors.
The Seasiders took the lead 27 minutes into the game. Midweek hat-trick hero John Murphy had already seen Brentford keeper Paul Smith make a superb save from one 18th minute effort when he gave his side the lead with a second attempt at a shot on the turn after being fed by Paul Evans.
Smith again denied Murphy from an Evans cross a few minutes later while the best Brentford could manage was a tame shot from Rowan Vine after a one-two with Stephen Hughes put him clean through on 33 minutes.
The second half was a different affair as the hard working Bees put the pressure on Pool.
The first real chance of the half, however, came when a tricky run from Blackpool's danger man Martin Bullock saw the ball cut back to Keith Southern who shot just over the bar.
Brentford's attacking threat increased even further when big substitute Mark McCammon replaced Hughes after 58 minutes.
Former Scotland skipper Colin Hendry showed all of his international experience to deny McCammon when he appeared to have a clean run on goal after 72 minutes and, with ten minutes left, Barnes showed his value when he superbly tipped a Matt Somner header over the bar when an equaliser looked certain.
Blackpool boss Steve McMahon said afterwards: "I was pleased with our attitude today, this was an important game which we could easily have lost."
Bees defender Michael Dobson added: "The chances we are getting are quite simple and ought to be in the back of the net, we are defending quite well but we are giving the ball away too easily and putting ourselves under pressure."