Brentford were boosted before the game with the return of Darren Powell and Ben Burgess following hamstring injuries, whilst Martin Rowlands was able to play despite his injury on Easter Monday.
Brentford were dominant from start to finish and were forcing free kicks and corners deep into Huddersfield territory in the opening minutes. Paul Evans had shot saved by Margetson in the visitors goal and the keeper also had to clear efforts from Steven Sidwell and Michael Dobson.
Huddersfield thought they had taken the lead when Leon Knight deflected a Schofield shot past Paul Smith, but he was in an offside position.
Brentford did however take the lead just before the half hour. Margetson failed to hold a free kick by Evans and Lloyd Owusu poked in his 21st goal of the season from close range.
Rowlands had an effort sail over the bar from a tight angle and Huddersfield came very close to equalising when Gareth Evans' cross shot whistled just over.
Brentford doubled their lead after 35 minutes; Owusu did excellently to hold off the challenges of 3 defenders before laying the ball to Sidwell who shot home from 25 yards.
2-0 became 3-0 just 5 minutes later. Smith collected a corner and released Ijah Anderson who attacked down the left flank. After some interplay with Stephen Hunt his cross found Martin Rowlands. He cut inside a defender before slotting The Bees into an unassailable lead.
Brentford came out in the second half and went for more goals, while Huddersfield attempted to regain some pride.
Early in the second period Margetson produced a world-class save to prevent Dobson making it 4-0 but was helpless when an Evans free kick crashed off the crossbar and was cleared to safety.
Huddersfield had more of the game in the second period and Knight was always a danger down the right side. However they never really came close to scoring and it was only through a series of corners that they pressured the home goal.
Brentford made 3 changes before the end of the game, Boxall, McCammon and Theobold replacing Rowlands, Powell and Owusu, as the game drew to a close.
As the game ended Brentford had got the first of the 3 victories needed to take them into the first division, they now know that with 2 games to go 6 points will see them playing first division football next season.
Brentford: Smith, Dobson, Anderson, Powell (Theobold), Ingimarsson, Rowlands (Boxall), Evans, Sidwell, Hunt, Owusu (McCammon), Burgess
By Chris Wickham